In periapical granulomas cell-mediated and humoral immune reactions occur in response to bacterial toxins or dead cells that are present in infected root canals. They are composed by B and T lymphocytes, plasmocytes, macrophages, some PMN leucocytes, mastocytes and multinucleated giant cells. The behavior of these cells in apical granulomas is strongly influenced by various inflammatory mediators. During the presentation, we will do an interesting trip within a human apical granuloma to see “in toto” the granulomatous cell interactions and their relationship with the mechanisms of the tissue repair as normally occurred after endodontic treatment in different clinical situations.
Learning Objectives :
- Although various types of immunocompetent cells have been historically described in human periapical granulomas, the literature concerning their spacial configuration and interaction is not extensive. Therefore, the learning objective of this presentation was to get a comprehensive knowledge on the behavior and role of these cells in the repair process of different clinical cases when proper endodontic therapy was done.
